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May 15, 2020Open    AccessArticle

Targeting Three-Dimensional Genome Architecture Might Be One of the Mechanisms of Chloroquine’s Diverse Therapeutic Actions

Gao-De Li
Chloroquine (CQ) was initially synthesized as an antimalarial agent, but later on, it also shows immunomodulatory, anticancer, and antiviral effects in clinical practice. Although CQ has been used to treat various conditions for more than half century, the underlying mechanisms of its diverse therapeutic actions remain incomplete. In this paper, we hypothesize that targeting three-dimensional genome architecture might be one of the mechanisms of CQ’s diverse therapeutic actions. Based on this hy...


May 15, 2020Open    AccessArticle

Déja vu and Wind Turbines: A Review of Lived Experiences after Appeals of Ontario Industrial-Scale Wind Power Facilities

Jane Wilson, Carmen Krogh, Paula C. Peel
This paper is a review of reports of lived experiences of residents in rural/small-town Ontario, Canada and a comparison to the concerns raised during citizen-sponsored appeals of industrial-scale wind power project approvals. We found that the concerns leading to the decisions to appeal power projects have been borne out in real-life experience, as government documents record thousands of complaints about adverse effects on the environment and human health. These findings support the need for e...


May 15, 2020Open    AccessArticle

Magnetic Characterization of the Carajás Mineral Province, Brazil

Yasmim Monteiro Cordeiro, Gleyton Pinto Lisboa, Vinny Sales Esterque, Hans Schmidt Santos, Larissa Santos de Paula, Orlandemberg Pereira Silva
This work presents the magnetometric method application in the Carajás Mineral Province, located in the south of the Pará state, Brazil. This is a region rich in iron ore in hematite form distributed in the Itacaiúnas Belt. The available gross magnetometric data were corrected and subtracted from the IGRF (International Geomagnetic Reference Field). Subsequently, magnetic anomaly, vertical derivative, horizontal derivatives and analytical signal maps were made that allowed to identify the main f...


May 13, 2020Open    AccessArticle

Enhanced Power and Ground Mesh Structure for IR-Drop Reduction

Vakhtang Janpoladov, Suren Abazyan
New enhanced power/ground mesh structure is presented for voltage drop (IR drop) reduction on power distribution network in integrated circuits (ICs). The new structure focuses on the length of the overall power/ground mesh wire pattern, reducing it by using a complex dotted line wire pattern instead of the usual mesh straps, which brings to wire length reduction on almost 40%, while via count on changed metal layer remained the same. Measurements of the voltage drop prove that with proposed mes...


May 13, 2020Open    AccessArticle

A Radiological Survey in Tailings: A Case Study of Rosterman Gold Mine, Western Kenya

Conrad Khisa Wanyama, John Wanjala Makokha, Fred Wekesa Masinde
Thirty samples of tailing waste weighing 200 g were randomly collected from both active and inactive tunnels at the Rosterman gold mine site in western Kenya. The average activity concentration of the radionuclides (40K, 232Th and 238U) analyzed by the gamma-ray spectrometry in the tailing samples was 260 ± 14.29 Bq/Kg for 40K, 118 ± 8.25 Bq/Kg for 232Th and 81 ± 3.63 Bq/Kg for 238U. The corresponding radiological parameters for all the collected thirty tailing waste samples were determined from...


May 12, 2020Open    AccessArticle

Remarks on the Order of Quantum Equations of Motion

Eliahu Comay
The paper examines the Dirac-Pauli differences concerning the order of the primary differential equation of an elementary massive quantum particle. The analysis relies on several self-evident constraints that an acceptable quantum theory must satisfy, like conservation laws, compatibility with Maxwellian electrodynamics and the correspondence principle. The dimension of the quantum function that is used in the Lagrangian density of a given quantum theory together with the corresponding different...


May 12, 2020Open    AccessArticle

The Prevalence of Musculoskeletal Complications in Type 2 Diabetes Mellitus

Mayssoun Kudsi, Louay Labban
Background: The numbers of Diabetes Mellitus (DM) cases are increasing worldwide. DM cause chronic damage to many body organs. A number of musculoskeletal conditions have been linked to Diabetes Mellitus which include some affecting the shoulders (i.e. adhesive capsulitis and rotator cuff tendinopathy, carpal tunnel syndrome, neuropathic arthropathy), the hands (limited joint mobility, and diabetic sclerodactyly) and several other conditions. These health issues are important to identify because...


May 11, 2020Open    AccessArticle

Foresight Look on the Disinfection By-Products Formation

Djamel Ghernaout, Noureddine Elboughdiri
In the water treatment industry, if there is a process that has attracted polemic discussion in terms of pros and cons disinfection has attracted the main part for its disinfection by-products (DBPs) formation. This work focuses on DBPs precursors, link among disinfection and DBPs, DBPs elimination, and study futures. During the last half-century, chlorination has been shown highly toxic to human health. Indeed, as a classical disinfectant, chlorine generates a bigger number of halogenated by-pr...


May 11, 2020Open    AccessArticle

Relationship between Personality Traits and Course Subjective Well-Being: Mediating Effect of Self-Efficacy

Dong Yang, Xiaohui Yang, Hanhui Chen, Deliang Sun
More and more courses are no longer based on the examination results to evaluate the effect. As the main participants, students are paid more attention to, especially their mental feelings. This paper explores the mediating effect of self-efficacy and the mutual relationship between personality traits and course subjective well-being. A questionnaire was conducted among 310 students in the course “comprehensive experiment of management”, correlation and regression methods were used to investigat...


May 11, 2020Open    AccessArticle

Deep Learning Convolution Neural Network to Detect and Classify Tomato Plant Leaf Diseases

Thair A. Salih, Ahmed J. Ali, Mohammed N. Ahmed
The tomato crop is an important staple in the ?market and it is one of the most common crops daily ?consumed. Plant or crop diseases cause reduction of quality and quantity of the production; therefore detection and classification of these diseases are very necessary. There are many types of diseases that infect ?tomato plant like (bacterial spot, late blight, sartorial leaf ?spot, tomato mosaic and yellow curved). Early detection of plant diseases increases production and improves its quality. ...


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